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Analysis of twin pairs in which both responded to the questionnaire,and a question on stroke,indicated proband concordance rates of 17.7%for monyzygotic pairs and 3.6%for dizygotic pairs(relative risk=4.3;x2=4.94, df=1;p<0.05).This nearly fivefold increase in the prevalence of stroke among the monozygotic compared with the dizygotic twin pairs suggests that genetic factors are involved in the etiology of stroke.The twin study paradigm holds considerable promise for identifying both genetic and environmental influences on stroke. |
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